What are the official methods of moisture content determination?
Numerous methods are used to determine the moisture content of various materials. The most commonly employed methods are:
- Gravimetric Method
- Karl Fischer Titration
- Resolution Analysis Method
- Microwave Drying Method
- Infrared Drying Method
- Nuclear Magnetic Resonance (NMR) Method
The Resolution Analysis Method is commonly utilized in the pharmaceutical industry to assess the moisture content of tablets, capsules, and pharmaceutical excipients.
Resolution Analysis Method
The Resolution Analysis Method is a quantitative analytical technique that involves the use of chromatography to separate and quantify the components of a sample. In the context of moisture content determination, this method employs a gas chromatograph equipped with a special detector that can selectively detect water vapor.
The Resolution Analysis Method is advantageous due to its:
- Accuracy
- Sensitivity
- Specificity
- Suitability for a wide range of sample types
The steps involved in the Resolution Analysis Method are:
- Sample preparation
- Chromatographic separation
- Detection and quantification
The Resolution Analysis Method is a reliable and accurate method for determining the moisture content of various materials, particularly pharmaceutical products.